Robshaw has had an outstanding campaign for Quins
Harlequins duo Chris Robshaw and Jordan Turner-Hall are among the four debutants named in the England side to play the Barbarians on Saturday.
Blind-side flanker Robshaw and centre Turner-Hall were named Premiership player of the season and young player of the season after superb campaigns.
Uncapped Newcastle prop David Wilson and Bath wing Matt Banahan also start.
Flanker Lewis Moody takes the open-side jersey after a 15-month absence, while Steve Thompson is named on the bench.
World Cup-winning hooker Thompson, who now plays for French side Brive, makes his first appearance in an England 22 since 2006.
Thompson quit the game in 2007 because of what was thought to be a career-ending neck injury but made a comeback for French club Brive at the end of that year.
Northampton hooker Dylan Hartley makes his first start as does versatile Saints team-mate Ben Foden, who is given the number 14 shirt.
Hartley has won nine caps off the bench, while Foden claimed his first and only cap as a replacement for scrum-half Harry Ellis in this year's Six Nations match against Italy.
Two possible debutants are named on the bench, Gloucester prop Nick Wood and Newcastle back Tom May.
Moody is back in an England team for the first time since suffering an Achilles injury against Wales in February, 2008.
The 30-year-old had an ankle operation last year before being ruled out of the 2009 Six Nations after breaking his ankle.
With Toby Flood and Jonny Wilkinson injured and Danny Cipriani named in the second-string Saxons squad, Brive's Andy Goode takes the fly-half role alongside scrum-half Danny Care.
Turner-Hall, 21, played a key role in a successful Harlequins campaign, scoring six tries in 30 appearances as they finished second in the Premiership table as well as reaching the Heineken Cup quarter-finals.
Robshaw, 22, who won the Churchill Cup with the Saxons last year, started all but one of his side's Premiership matches.
With England supplying nine players to the British and Irish Lions tour, there are only three survivors from the last game against Scotland - skipper Steve Borthwick, number eight Nick Easter and full-back Delon Armitage.
Armitage was a serious contender to receive a late call-up for the Lions but Wales fly-half James Hook was selected ahead of him as a replacement for Leigh Halfpenny.
Although the Twickenham contest is a non-cap international, the players will be keen to impress manager Martin Johnson ahead of the two Tests against Argentina.
The matches take place at Old Trafford on 6 June and Salta, Argentina on 13 June.
England: D Armitage (London Irish); Foden (Northampton), Noon (Newcastle), Turner-Hall (Harlequins), Banahan (Bath); Goode (Brive), Care (Harlequins); Payne (Wasps), Hartley (Northampton), D Wilson (Newcastle), Borthwick (Saracens, capt), L Deacon (Leicester), Robshaw (Harlequins), Moody (Leicester), Easter (Harlequins).
Replacements: Thompson (Brive), Wood (Gloucester), Jones (Sale Sharks), S Armitage (London Irish), Haskell (Wasps), Hodgson (London Irish), May (Newcastle).