Jamie Noon stops powerhouse centre Seru Rabeni in his tracks
Leicester (27) 41
Tries: Corry, Crane, J Murphy, Ayerza
Cons: Goode 3
Pens: Goode 4
Newcastle (9) 14
Pens: Wilkinson 3
Two tries inside the opening 12 minutes from Martin Corry and Jordan Crane put Leicester on course for a win which puts them second in the Premiership.
Andy Goode added four penalties before the break and although Jonny Wilkinson slotted three kicks for Newcastle, they trailed 27-9 at half-time.
Toby Flood crossed for Newcastle three minutes after the interval.
But Leicester wrapped up victory and a four-try bonus point as Johne Murphy and Marcos Ayerza added further tries.
In total Goode kicked 21 points, but he blotted his copybook as he picked up a yellow card for a high tackle - his second in two matches - after 67 minutes.
Julian White was missing for Tigers after being handed a seven-day ban by the club following last week's yellow card against Leinster.
But the hosts welcomed back big guns Corry, Lewis Moody, George Chuter, Ben Kay and Aaron Mauger.
And Corry marked his return to the side after just four minutes when he took a long pass on the left, brushed off a challenge and ran through unopposed from 20m to touch down in the left-hand corner.
Goode missed the conversion from near the left-hand touchline and Wilkinson put Newcastle on the board with a sixth minute penalty.
Corry powers over with Mathew Tait unable to prevent the first try
But the Tigers soon extended their lead as Crane used Tom Varndell as a decoy outside before crashing over, with Goode adding the extras to make it 12-3 after 12 minutes.
The rest of the first-half scoring came from the boot with Goode landing four penalties to two from Wilkinson to give Leicester a healthy 18-point lead at the break.
Newcastle looked like they might get back in the game three minutes after the restart as Flood went over.
But Leicester hit back just two minutes later through Johne Murphy, Goode once again on target with the conversion.
And they secured the four-try bonus point after 52 minutes when a catch and drive ended with Ayerza touching down for another converted try.
Leicester boss Marcelo Loffreda on the effect of being knocked out of the Heineken Cup:
"We had to come back from that. That was the challenge and we have to be very satisfied.
"We have to focus on what we can achieve and build our confidence and we are doing that really well.
"We tried to be consistent and build on last week and we were really good."
Loffreda on Lewis Moody:
"He's a great talent and has a great mindset. He is one of the leaders of English rugby."
Falcons boss John Fletcher:
"We didn't get out of the blocks. We needed a good start and we got off to the worst possible start.
"We conceded a couple of early tries and Leicester's not a good place to be chasing. We gave them far too much space, they got points on the board and built momentum.
"I couldn't wait for half-time, so we could regroup. We created some half chances after that in the second half but lacked that bit of precision."
Leicester: G Murphy, J Murphy, Rabeni, Mauger, Varndell, Goode, F Murphy, Ayerza, Chuter, Castrogiovanni, L Deacon, Kay, Corry, Moody, Crane.
Replacements: Kayser, Young, Wentzel, B Deacon, B Youngs, Humphreys, O Smith.
Newcastle: M Tait, May, Noon, Flood, Rudd, Wilkinson, Grindal, Golding, Long, Hayman, Perry, Sorenson, B Wilson, Woods, Winter.
Replacements: Thompson, Ward, Parling, Dowson, Dickson, Visser, Phillips.