Uncapped Wasps flanker James Haskell has been named in England's 28-man squad for the Six Nations clash with France at Twickenham on 11 March.
Haskell has played for England Saxons this year
Mark Cueto, Jason Robinson, Mike Catt, Tim Payne, Steve Borthwick and Nick Easter have also been added to the 22 that faced Ireland last weekend.
Gloucester full-back Olly Morgan is out after suffering a season-ending shoulder injury against Ireland.
Robinson (neck) and flanker Magnus Lund (concussion) remain injury doubts.
"I will be monitoring the progress from their injuries of Jason Robinson and Magnus Lund," said England coach Brian Ashton.
Haskell, 21, who has two tries in 12 league appearances for Wasps this season, helped England Under-21s claim the Grand Slam in 2006.
The blind-side flanker or number eight was promoted to the Saxons side this year for the wins over Italy A and Ireland A.
"I'm obviously very, very excited about it," he said. "It's going to be a huge opportunity for me to learn from players and coaches at the highest level of the game.
"Brian Ashton has said that he is picking players on form, so obviously it is a huge compliment to have been selected as a result of my recent playing performances.
"But that also means you are only as good as your last game, and for me Wasps have a huge game against Bristol this weekend."
Borthwick returns to an England squad for the first time since last year's Six Nations after recovering from a ligament tear in his knee.
He played in Bath's first two matches of the season, but did not take the field again until 6 January.
And the selection of the Bath lock will put pressure on second rowers Danny Grewcock and Louis Deacon.
"It's been a long road to try and fight my way back," he said. "It was certainly a frustrating time being out injured. It's great to be back playing and I'm really enjoying it."
Morgan's injury, combined with the inclusion of Sale wing Cueto, raises the possibility of Josh Lewsey moving from the wing to full-back for the France match.
Cueto, scorer of 13 tries in 18 Tests, has not featured for England since Andy Robinson's last game in charge against South Africa last November.
With the correct rest and rehab, Jason Robinson should be back playing very soon
Sale club doctor Dave Jones
He has suffered abductor and calf muscles since then but recently returned to club action.
Robinson injured his neck during England training in Bath last Wednesday and did not recover in time for the Dublin contest.
The 32-year-old winger saw a specialist on Tuesday night and was advised to rest for a few days to let the neck pain settle down.
"The good news is that the problem should not need any corrective surgery," said Sale club doctor Dave Jones. "With the correct rest and rehab, Jason should be back playing very soon."
If Robinson is fit, it looks as if he will battle with Cueto and David Strettle of Harlequins for the wing berths.
Strettle impressed on his debut against Ireland and claimed a well-taken second-half try.
Lund came off at half-time against Ireland because of concussion and Jones added: "Magnus will not play again until he has taken and passed the necessary tests.
"It is very doubtful he will play against Saracens this weekend but we are hopeful he will be fit next week."
Ashton is due to name his starting line-up next Tuesday and will be hoping that his players come through unscathed after this weekend's Premiership games.
England squad for Six Nations game with France:
Backs: Lewsey (Wasps), Robinson (Sale), Cueto (Sale), Strettle (Harlequins), Tait (Newcastle), Tindall (Gloucester), Farrell (Saracens), Catt (London Irish), Wilkinson (Newcastle), Flood (Newcastle), Ellis (Leicester), Perry (Bristol).
Forwards: Freshwater (Perpignan), Vickery (Wasps, capt), White (Leicester), Payne (Wasps), Chuter (Leicester), Mears (Bath), Deacon (Leicester), Grewcock (Bath), Borthwick (Bath), Palmer (Wasps), Easter (Harlequins), Worsley (Wasps), Haskell (Wasps), Lund (Sale), Rees (Wasps), Corry (Leicester).