Sale Sharks wing Mark Cueto will return to action when England Saxons play Ireland A in Belfast on Friday.
Cueto has scored 13 tries in 18 Tests
Cueto, who has 18 senior caps, missed out on England's opening Six Nations appointments with Scotland and Italy due to groin and calf muscle problems.
Scrum-half Shaun Perry has been promoted to the senior squad and is replaced by Peter Richards.
And former Great Britain rugby league star Chev Walker, now of Bath, gains his first international start in union.
Cueto replaces Bath wing Nick Abendanon, and Saxons coach Jim Mallinder said: "We know what Mark is capable of, and this is a good chance for him to regain some match fitness.
"It is tough on Nick Abendanon, who I thought had a great game against Italy A in Exeter last Friday.
"This is a good chance for us to have a look at Chev. He did well with the little game-time he got last week, and he fully deserves his place."
London Irish centre Mike Catt will captain a Saxons side that also includes a back-row opportunity for Chris Jones.
Promising Northampton hooker Dylan Hartley also starts and Newcastle flanker Ben Woods gains a chance on the bench.
England Saxons: M Brown (Harlequins); M Cueto (Sale Sharks), C Walker (Bath), M Catt (London Irish, capt), D Strettle (Harlequins); S Geraghty (London Irish), P Richards (Gloucester); T Payne (Wasps), D Hartley (Northampton), S Turner (Sale Sharks), D Schofield (Sale Sharks), A Brown (Gloucester), C Jones (Sale Sharks), J Scaysbrook (Bath), J Crane (Leicester).
Replacements: A Titterrell (Sale Sharks), N Wood (Gloucester), B Woods (Newcastle), J Haskell (Wasps), R Wigglesworth (Sale Sharks), O Barkley (Bath), N Abendanon (Bath).