Bristol will travel to Gloucester in the Powergen Cup quarter-finals, after being re-instated following Wasps' disqualification from the competition.
Wasps beat Bristol 43-33 in extra time, but were then deemed to have fielded an ineligible player by the RFU.
The other ties, to be played on the weekend of 21/22 January, feature three other all-Premiership clashes.
Sale host Bath, Northampton face Leeds at Franklin's Gardens while Saracens entertain London Irish.
Gloucester's managing director Ken Nottage said the sudden change of opponent would not affect ticket sales or preparation for the tie.
"We've already sold a few thousand tickets for the quarter-final, but we will welcome the opportunity for a thrilling West Country derby against Bristol Shoguns.
"We believe that the derby against Bristol is as big a game as the original fixture."
Gloucester aim to keep the same kick-off time of 1445GMT on 22 January and will honour any tickets already purchased for the original fixture against Wasps.
Meanwhile, Sale - losing finalists last year - and Bath will also be familiar foes.
"It's a very tough draw for us," said Bath coach John Connolly.
"Sale are a very dangerous side containing some outstanding players and we will have to be at our best."
The four National League One sides defeated in the sixth round over the weekend will face each other in the semi-finals of the Powergen Challenge Shield.
Plymouth Albion, beaten at Sale, will take on Bristol, while Pertemps Bees (formerly Birmingham & Solihull) host Bedford.
Powergen Cup quarter-finals:
Gloucester v Bristol
Saracens v London Irish
Sale Sharks v Bath
Northampton Saints v Leeds Tykes
Ties to be played weekend of 21-22 January, 2005
Powergen Challenge Shield semi-finals:
Plymouth Albion v Bristol
Pertemps Bees v Bedford
Ties to be played weekend of 5-6 March, 2005