Leicester (13) 46 Tries: Castrogiovanni, Youngs, Waldrom, Croft 2, Murphy Cons: Flood 5 Pens: Flood 2 Scarlets (10) 10 Tries: Stoddart Cons: S Jones Pens: S Jones
Tom Waldrom, caught in the middle of this melee, scored Leicester's third try
Leicester responded spectacularly after going behind to a Scarlets try as they overpowered their Welsh opponents.
A brilliant move rounded off by Morgan Stoddart put the visitors ahead, but Leicester led 13-10 at half-time after a Martin Castrogiovanni touchdown.
Leicester had an extra man at the start of the second half and quickly ran in tries from Ben Youngs, Tom Waldrom and Tom Croft, all converted by Toby Flood.
With the bonus point secured, Croft and Geordan Murphy added two more tries.
The calming presence of Flood, making his return from injury, proved a vital cog in the Tigers machine, but New Zealander Waldrom at number eight was the stand-out individual, with a combination of incisive runs and some crunching tackles.
Two wins from two in the Heineken Cup puts Leicester top of the group, leading Perpignan, 35-14 winners over Treviso earlier on Sunday, by four points.
Leicester looked far better than the side who have lost three of their first five matches in the Premiership, despite an early wobble.
The Scarlets looked dangerous during an enterprising win over Perpignan in their European opener and headed to the east Midlands looking to become the first Welsh side to win here in Europe.
But, after a lively opening, they were ground down and suffocated by Leicester's physicality and forward prowess as their scrum and lineout crumbled.
A deliberate knock-on from Tigers' wing Alesana Tuilagi prevented Rhys Priestland putting Sean Lamont over down the left, earning the Samoan a yellow card.
The Llanelli-based team made the extra man count in the 15th minute as Regan King launched a terrific move from his own 22, releasing Lamont to race clear. After a couple more passes, Stoddart dotted down for a magnificent try, converted by Jones.
But the lead lasted all of two minutes. Leicester took advantage of a blatant forward pass, missed by referee George Clancy, to send Matty Smith charging down the right.
Flood's return after a month out with a knee injury helped settle Leicester
The ball went loose but the Tigers' pack regathered to drive Castrogiovanni over, Flood's conversion levelling the scores.
A period of sustained Leicester pressure followed, but the west Wales side defended well in the main, as two Flood penalties and one from Stephen Jones gave the home side a three-point lead at half-time.
The Welsh side saw Wales prop Rhys Thomas stretchered off with a knee injury, Deacon Manu his replacement, and with King - sin-binned on 33 minutes - still off the field when the second half started Leicester turned on the style.
A sniping, opportunistic score from Youngs gave Leicester a 10-point lead once the try had been converted.
Even with King back on the field moments later, Leicester remained dominant. Poor Scarlets defending allowed Youngs to feed Waldrom for a simple try after a quick tap following the award of a free kick.
The bonus point was secured after 51 minutes when captain Murphy intercepted King's pass and set up Croft, and a fifth Leicester try duly arrived when Tuilagi pounced on a loose ball in his own 22 and kicked deep into the visitors' territory.
Lamont picked up the loose ball but was tackled in front of his own sticks and the turnover ball was moved wide for Croft to saunter in for his second try.
The rout was completed when Murphy burst onto a flat pass from replacement Billy Twelvetrees.
In Perpignan, a late flurry of points gave the French side their first victory of their European campaign..
The teams were locked at 14-14 with 20 minutes remaining but the hosts broke free with a penalty try before Gerrie Britz and Damien Chouly crossed in the closing stages.
Leicester: Murphy, Hamilton, Smith, Allen, A. Tuilagi, Flood, Youngs, Ayerza, Chuter, Castrogiovanni, Slater, Skivington, Croft, Newby, Waldrom. Replacements: M. Tuilagi for Allen (59), Grindal for Youngs (56), Stankovich for Ayerza (64), Duffey for Chuter (76), Cole for Castrogiovanni (56), Mafi for Croft (67), Woods for Newby (64). Not Used: Twelvetrees. Sin Bin: A. Tuilagi (7).
Scarlets: Priestland, Stoddart, King, Maule, Lamont, S. Jones, Roberts, I. Thomas, Rees, R. Thomas, Reed, Cooper, Turnbull, McCusker, Lyons. Replacements: Evans for King (70), Knoyle for Roberts (51), R. Jones for I. Thomas (70), Manu for R. Thomas (35), J. Edwards for Cooper (59). Not Used: Owens, Welch, S. Williams. Sin Bin: King (33).
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