Toulouse clinched a record fourth European crown in May
Wasps, Glasgow and Dragons have been drawn in the same group as reigning champions Toulouse in Pool 6 of the 2010-2011 Heineken Cup.
French newcomers Racing Metro 92 face Leinster, Clermont and Saracens.
Munster, Ospreys and London Irish are in Pool 3, with Leicester and Scarlets coming together in Pool 5.
Bath face Ulster in Pool 4 as well as Italian newcomers Aironi, while Pool 1 features Cardiff, Northampton, Edinburgh and French side Castres.
The 16th Heineken Cup gets under way in early October, with the final at Cardiff's Millennium Stadium in the Welsh capital on 22 May.
Premiership champions Leicester's biggest threat is arguably Perpignan, who finished top of the French league last season.
Pool 3 looks particularly tough, with Magners League champions Ospreys and Jonny Wilkinson's ambitious Toulon meeting two-time winners Munster.
Biarritz, who narrowly lost last month's final against Toulouse 21-19, are in the group featuring Bath and Ulster.
Pool 1: Cardiff Blues, Northampton, Edinburgh, Castres Olympique
Pool 2: Leinster, ASM Clermont Auvergne, Saracens, Racing Metro 92
Pool 3: Munster, Ospreys, London Irish, Toulon
Pool 4: Biarritz, Bath, Ulster, Aironi Rugby
Pool 5: Leicester, Scarlets, Perpignan, Benetton Treviso
Pool 6: Toulouse, London Wasps, Glasgow Warriors, Newport Dragons