Douglas were knocked out of the RFU Vase 23-11 by Whitehaven at Port-e-Chee Meadow on Saturday.
Bryn Snellgrove kicked two penalties to give the Manx side an early advantage before tough tackling Whitehaven took control to lead 13-6 at half-time.
A Mike Hebden try in the second-half gave Douglas hope but in the end Whitehaven proved to be too strong.
Meanwhile Ramsey beat Sourthern Nomads 35-19 to reach the semi-finals of the Cheshire Plate.
The Northerners delivered an assured performance and progress to the last four 85-22 on aggregate.
Castletown moved away from the bottom of the Shimmin Wilson Shield table in some style with a 32-10 won over Vagabonds B at Glencrutchery Road.
Results, 6 February
RFU Senior Vase
Douglas 11-23 Whitehaven
Cheshire Cup Qualifier second leg
Southern Nomads 19-35 Ramsey
(Ramsey win 85-22 on aggregate)
Shimmin Wilson Manx Shield
Vagabonds B 10-32 Castletown
Ramsey B 70-0 Emerging Nomads