Spies had played in all nine Springboks Tests so far this year
South African back-row player Pierre Spies has been forced to pull out of the squad for their European tour after an operation on a broken finger.
Spies suffered the injury playing for the Blue Bulls in the Currie Cup and has been replaced in the Springboks touring party by Jean Deysel.
South Africa take on Leicester on Friday before the first Test of the tour against France on 13 November.
They will also play Italy, Ireland and Saracens during the tour.
Flanker Juan Smith was not considered for the tour because of injury, while centre Jean de Villiers and full-back Francois Steyn, who were also members of the victorious Tri-Nations squad, also miss the tour because of overseas club commitments.
Coach Peter de Villiers included nine new caps in his original touring party, as he continues to rebuild the squad which won the World Cup two years ago.
"We're number one in the world and we seriously want to stay there," said de Villiers.
"We are looking ahead so we can stay number one for many years.
"We don't want to be caught with our pants down when the first-stringers all leave the scene at the same time.
"There's still life after the 2011 World Cup and we want to leave a legacy for whoever takes over.
"It will be make or break for some of these new players and I want to see whether they have reached their ceiling or whether they can still grow."
Revised South African tour squad for European tour: John Smit, Victor Matfield, Andries Bekker, Bakkies Botha, Heinrich Brüssow, Schalk Burger, Bismarck du Plessis, Jannie du Plessis, Alistair Hargreaves, Ashley Johnson, Ryan Kankowski, Bandise Maku, Tendai Mtawarira, Dewald Potgieter, Chiliboy Ralepelle, Davon Raubenheimer, Danie Rossouw, Jean Deysel, Gurthro Steenkamp, Heinke van der Merwe, Heini Adams, Meyer Bosman, Juan de Jongh, Fourie du Preez, Jaque Fourie, Bryan Habana, Francois Hougaard, Adrian Jacobs, Zane Kirchner, Odwa Ndungane, Jongikhaya Nokwe, Wynand Olivier, Ruan Pienaar, JP Pietersen, Earl Rose, Morne Steyn, Riaan Viljoen.