Prop Gethin Jenkins cracked a cheekbone on Pretoria
The British and Irish Lions have lost both props for the third and final Test against South Africa next weekend.
Gethin Jenkins and Adam Jones were both injured in the 28-25 second-Test defeat and had operations on Saturday, with five Lions sent to hospital in total.
Jenkins has a broken cheekbone and Jones dislocated his shoulder.
Brian O'Driscoll (concussion) and Jamie Roberts (wrist) are major doubts, but Ronan O'Gara (eye cut) and Tommy Bowe (elbow) should be fit for selection.
Head coach Ian McGeechan, who confirmed the Lions would not be calling up any replacements, said the loss of Jenkins, Jones, O'Driscoll and Roberts had a major bearing on the second Test.
Adam Jones dislocated a shoulder in the second half
"There is no doubt the four serious injuries affected the tempo of our game and our decision-making and accuracy," he said.
"I don't think the uncontested scrums helped us either. We were working the big Boks forwards around and it became a soft platform after that.
"Losing the two props was a massive blow. I think the game would have been different if they had stayed on."
Jenkins was injured in a clash of heads with Springboks winger Bryan Habana while Jones left the field at the same time, forcing the introduction of uncontested scrums, after being taken out by Bakkies Botha.
The Springbok lock was cited for the incident, while his team-mate Schalk Burger was also charged following an incident in the first minute of the match.
Lions doctor James Robson said: "It certainly was a fairly brutal game.
"As the casualty list goes it is not something I am happy with. To lose two of our most colourful characters in Gethin and Adam is distressing.
"Gethin has had a plastic plate inserted. The timescale for his recovery is six to eight weeks.
"We couldn't get Adam's shoulder to pop back in at the stadium and he was required to go to theatre. He will be subject to further investigation and specialist opinion.
"Brian is very much alert and conscious today (Sunday) but he is subject to the usual return-to-play protocol."
Saturday's defeat in Pretoria means the Lions head to Johannesburg for the third Test with the hosts holding a decisive 2-0 lead in the series.