Ledesma returns after losing the Top 14 final in France with Clermont
Clermont Auvergne hooker Mario Ledesma is one of three changes to Argentina's squad for the second Test against England in Salta this weekend.
Cordoba Athletic flanker Genaro Fessia and Perpignan lock Rimas Alvarez also come in as Mariano Sambucetti, Alvaro Tejada and Alejandro Abadie drop out.
The Pumas lost 37-15 to England at Old Trafford on Saturday.
"We have a chance for revenge and we must improve," said number eight Juan Manuel Leguizamon.
"It was a very tough match and we gave away too many fouls. The rivals know where the opponents' weak points are and force you to make those mistakes. We still have to keep training very hard."
Argentina squad: M Ledesma (Clermont Auvergne), G Camacho (Buenos Aires CRC), M Carizza (Biarritz), H Agulla (Brive), A Lalanne (London Irish), G Fessia (Cordoba Athletic), L Borges, F Aramburu, N Vergallo (all Dax), G Tiesi (Harlequins), S Fernandez (Hindu), M Ayerza (Leicester Tigers), M Avramovic (Montauban), R Alvarez (Perpignan), L Amorosino (Pucara), A Galindo (Racing Metro), J Orlandi (Rovigo), J Fernandez Lobbe (Sale Sharks), F Leonelli (Saracens), E Guinazu (Agen), J Hernandez, J Leguizamon, R Roncero (all Stade Francais), P Albacete, A Basualdo (both Stade Toulousain), E Lozada (Toulon).