Dan Parks returns at stand-off for Scotland's final RBS Six Nations match in Italy following Nikki Walker's withdrawal with an ankle injury.
Dan Parks returns at stand-off for Scotland
Coach Frank Hadden has decided to move Chris Paterson, who started at 10 against Ireland and England, to wing.
Simon Danielli and Fergus Thomson were called up to replace injured duo Rory Lamont and Ross Ford.
Andrew Henderson was a lated addition to the bench, where he will be joined by Sale hooker Scott Lawson.
Jason White, who began the campaign as captain, was again named among the replacements after the win over England.
Danielli will win his 15th cap, having appeared as a substitute against Wales earlier in the championship.
Hadden said: "Simon Danielli has played consistently well for some time now and I had no hesitation in giving him the chance to restart his international career."
Thomson, who was a first-half replacement for Ford at the weekend, will be making his first start having previously featured seven times as a replacement.
"Fergus Thomson played really well when he came on against England," added Hadden.
"He took his opportunity with both hands and thoroughly deserves his first start."
Hadden is looking to build on the 15-9 victory against England, while Italy are without a win so far.
"Saturday was another indication of the progress we feel we have made," said Hadden.
"After a very poor start to the Championship it's vital we maintain that progression this weekend against a side that will represent a formidable challenge."
Hadden had retained the five-two split between forwards and backs among the substitutes.
He explained: "We felt the impact made by the forward substitutes in the Calcutta Cup had a bearing on the outcome.
"We believe this is the right way to approach this game as well."
Scotland: Hugo Southwell (Edinburgh), Simon Danielli (Ulster), Simon Webster (Edinburgh), Graeme Morrison (Glasgow Warriors), Chris Paterson (Gloucester); Dan Parks (Glasgow), Mike Blair (Edinburgh, capt); Allan Jacobsen (Edinburgh), Fergus Thomson (Glasgow), Euan Murray (Northampton), Nathan Hines (Perpignan), Scott MacLeod (Llanelli Scarlets), Alasdair Strokosch (Gloucester), Allister Hogg (Edinburgh),Simon Taylor (Stade Francais)
Substitutes: Scott Lawson (Sale), Alasdair Dickinson (Gloucester), Craig Smith (Edinburgh), Jason White (Sale), Kelly Brown (Glasgow), Rory Lawson (Gloucester), Andrew Henderson (Glasgow Warriors).