Andy Nicol lifted the Calcutta Cup in 2000
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The bookmakers make England strong favourites to beat Scotland at Murrayfield on Saturday, but Phil Vickery and co would do well to cast their minds back to 2000 before getting too excited.
Eight years ago, England were red-hot favourites, just one win away from the Grand Slam as they travelled to Edinburgh for their final game of the 2000 Six Nations.
Clive Woodward's side had dominated throughout the tournament, convincingly winning all four of their matches.
Scotland, in complete contrast, were given no hope having lost all four of their games.
But form was turned on its head when fly-half Duncan Hodge scored all of Scotland's points in their shock 19-13 win in abysmal conditions.
BBC Sport spoke to two players who took the field at Murrayfield.
Every player has a game that defines his career in a Scotland jersey and that was mine.
It was just so unexpected. England had played four, won four - we had no right to win that game.
In 1990 (the last time Scotland had beaten England) there was a level of expectation because Scotland were going for the Grand Slam as well. But in 2000 it was billed as a lost cause.
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The euphoria and sense of satisfaction at the end was incredible
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It probably looked that way too when Lawrence Dalllaglio ran around me to score in the first few minutes!
But one of our tactics was definitely to ruffle them up a bit and put their key players like Matt Dawson and Jonny Wilkinson off their stride.
(Scotland's then coach) Ian McGeechan set down a game plan to beat them and the players learnt it all week.
That was the sense of satisfaction afterwards. We believed in it, executed it and really gave ourselves a chance, And the atmosphere in the last 10 minutes was just amazing.
People were incredulous. The euphoria and sense of satisfaction at the end were incredible.

Andy Nicol played 23 times for Scotland in a nine-year international career and is now a BBC Sport pundit.
He was talking to BBC Sport's Bryn Palmer
These days there is a lot more ceremony before internationals with bands walking across the pitch and all sorts of entertainment.
I remember that day they brought on these "Braveheart" actors, who were stomping up and down the ground, which is something you don't ordinarily experience on a rugby pitch.
There was a lot more going on than I had previously seen at Murrayfield - fireworks and fire, it was all really surreal.
Lawrence Dallaglio had put England ahead with an early first-half try
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At the start of the game, there was so much smoke from the fireworks going off that I struggled to see, it was quite an eerie night.
And then the weather just kicked in, which played into Scotland's hands.
They were in our faces and very aggressive. We started really well, scored a try through Lawrence Dallaglio and everything looked positive.
Throughout that whole tournament we played very open, very entertaining rugby - probably the best since I have been involved with England.
We came unstuck that night because we were used to playing this open brand of rugby and clearly the weather didn't permit us to do that.
It enabled them to really get under our skin - and ultimately win the game - which was gutting, to say the least.

Simon Shaw was talking to BBC Sport's Pranav Soneji
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