France have been forced to change their starting side for Saturday's RBS Six Nations clash with England after Romain Millo-Chluski withdrew injured.
Morgan Parra has beaten Dimitri Yachvili to the number nine jersey
The lock's Achilles problem means Pascal Pape comes into the second row with Jerome Thion now on the bench.
Scrum-half Morgan Parra makes his first Test start alongside Francois Trinh-Duc who replaces David Skrela at fly-half.
Number eight Louis Picamoles comes in for his first Test start with Julien Bonnaire switched to blind-side.
Fulgence Ouedraogo, who had started both Six Nations matches so far, drops to the bench as a result, with Thierry Dusautoir starting at open-side flanker.
"Picamoles can be our answer to England's physical power," said coach Marc Lievremont. "England's forwards are very experienced and very powerful with a hard-hitting back row.
"In the backline, they have a blend of speed and power. They don't always click collectively but when they do they are a very good team."
They don't always click collectively but when they do they are a very good team
France coach Marc Lievremont on England
Parra, who has appeared as a replacement in France's two wins over Scotland and Ireland, secures his first start after Jean-Baptiste Elissalde was ruled out with a calf injury.
Lievremont opted for the 19-year-old instead of Dimitri Yachvili, who was recalled to the France squad earlier this week following Elissalde's injury.
"Morgan has been with us for three weeks, he was convincing when he came on against Ireland and in training," explained Lievremont.
"He knows our calls on the set-pieces and we wouldn't have done Dimitri a favour if we had asked him to start the game."
Montpellier's Trinh-Duc, whose grandfather was Vietnamese, is regarded as a running rather than kicking fly-half and won his first cap as a starting number 10 in the opening Six Nations game against Scotland.
The 21-year-old lost his place to Skrela for the victory over Ireland but wins it back for the clash in Paris as France look to cement their title ambitions.
"We stayed true to our belief regarding the players and the style of play. We hope these young players will bring enthusiasm and cheek to the team," added Lievremont.
"Some people will make a fuss but we assume responsibility for our choices. We are not taking a gamble, we are not selling off Saturday's match because, revenge or no revenge, a game against England is always a special occasion."
Yachvili and prop Jean-Baptiste Poux, who was called up to replace the injured Julien Brugnaut, have to settle for places on the bench.
France had already lost full-back Clement Poitrenaud from their original squad with a broken ankle.
France team: Heymans (Toulouse); Rougerie (Clermont Auvergne), Marty (Perpignan), Traille (Biarritz), Clerc (Toulouse); Trinh-Duc (Montpellier), Parra (Bourgoin); Faure (Sale), Szarzewski (Stade Francais), Mas (Perpignan), Nallet (Castres, capt), Pape (Stade Francais), Bonnaire (Clermont-Auvergne), Dusautoir (Toulouse), Picamoles (Montpellier).
Replacements: Servat (Toulouse), J-B Poux (Toulouse), Thion (Biarritz), Ouedraogo (Montpellier), Yachvili (Biarritz), Skrela (Stade Francais), Floch (Clermont Auvergne).