New coach Marc Lievremont has named six uncapped players in his squad for France's Six Nations opener against Scotland at Murrayfield on 3 February.
France will have several changes from last year's winning team
Props Julien Brugnault of Dax and Lionel Faure of Sale earn call-ups.
So too do Albi lock Arnaud Mela, Bourgoin scrum-half Morgan Parra, Montpellier fly-half François Trinh-Duc and Clermont wing Julien Malzieu.
Sebastien Chabal, Jerome Thion, Clement Poitrenaud, Imanol Harinordoquy, Pierre Mignoni and David Marty are omitted.
In all, 11 of the World Cup squad have been dropped, including Lionel Beauxis, Yannick Nyanga, Remy Martin, Nicolas Mas and Sebastien Bruno.
Props Sylvain Marconnet, Pieter De Villiers and Olivier Milloud were not considered for selection because of injury, while Yannick Jauzion is also on the recovery trail after injury.
In addition Raphael Ibanez, Fabien Pelous, Christophe Dominici and Serge Betsen have all retired from internationals, while Frederic Michalak has taken a year off from Test duty to play Super 14 rugby in South Africa.
Only 11 of France's 30-man World Cup squad remain, with only eight of the 22 on duty against England in the World Cup semi-final still involved.
Castres lock Lionel Nallet will captain a much-changed line-up, the first chosen by Lievremont since he replaced Bernard Laporte after the World Cup.
France are bidding for a third successive Six Nations title.
Lievremont said: "Over the past three months, we have watched a lot of matches and followed the progress of French rugby. We have considered everyone.
"We took into consideration everything, the players in form and the team we are to be playing against."
French Rugby Federation president Bernard Lapasset described the coach's choices as "courageous."
Backs: Jean-Baptiste Elissalde, Morgan Parra, Francois Trin-Dhuc, David Skrela, Florian Fritz, Damien Traille, Vincent Clerc, Julien Malzieu, Cedric Heymans, Aurelien Rougerie.
Forwards: Julien Brugnaut, Lionel Faure, Jean-Baptiste Poux, William Servat, Dimitri Szarzewski, Loic Jacquet, Lionel Nallet, Arnaud Mela, Julien Bonnaire, Thierry Dusautoir, Fulgence Ouedraogo, Elvis Vermeulen.