Wasps scrum-half Eoin Reddan has earned a shock call-up as one of three changes for Ireland's World Cup must-win Pool D game against France on Friday night.
Wasps scrum-half Eoin Reddan starts against France
Heineken Cup winner Reddan replaces the dropped Peter Stringer while Isaac Boss is again named on the bench.
Andrew Trimble returns in place of Denis Hickie on the left wing.
Jerry Flannery replaces injured hooker Rory Best but Neil Best has to be content with a place on the bench while Geordan Murphy is left out of the 22.
Gavin Duffy is included on the bench at Murphy's expense while Simon Easterby is retained in the team despite Neil Best's physicality.
The promotion of Reddan comes out of the blue and ends Stringer's long association with his Munster colleague Ronan O'Gara at half-back.
Stringer, with 79 caps, is Ireland's second most-capped player behind Malcolm O'Kelly, who is again named on the bench.
Eoin Reddan's form at the end of the season for Wasps was very good
Ireland coach Eddie O'Sullivan
Reddan was the third choice coming into the World Cup - behind Stringer and Boss, who twice had limited time as a replacement in the games against Namibia and Georgia.
This will be the Limerick-born Reddan's fourth cap after making his debut as a replacement in the 2006 Six Nations game against France.
He made his first start during the summer tour to Argentina, where Ireland lost both Tests with a virtual reserve-strength side.
Reddan was with Munster twice and in between had a season with Connacht before being lured to London in 2005 by Warren Gatland, the former Ireland coach, who was then in charge of Wasps.
O'Sullivan said that dropping Stringer had been a difficult decision.
"Peter has been a star of the team but has been struggling a wee bit recently so that made the decision for us," said the Ireland coach.
"Eoin was given the nod on the basis of the game we want to play. His form at the end of the season for Wasps was very good.
"I told Peter the news and like every good player he accepts it comes with the territory.
Geordan's last few games against France haven't been a happy hunting ground
"Getting dropped happens to every player at some point.
"Isaac is a different type of player and can cover different positions, including full back, so that's why we kept him on the bench."
Trimble's pace and power means he is preferred over Hickie, who is retiring from all rugby at the end of the World Cup, after a one-match spell on the sidelines with a fractured finger.
"I wasn't unhappy with Denis' form but Andrew played well in the first game," said O'Sullivan.
The Ireland coach said that Murphy's errors in his last two displays against France, which saw the Leicester back gift Les Bleus a total of three tries, had convinced him to promote Duffy to the bench.
"Geordan's last few games against France haven't been a happy hunting ground. They have not been good days," he said.
"That's my decision and I stand over that. Gavin can cover wing, full-back and centre and that has also earned him the nod."
Ireland: Dempsey; Horgan, O'Driscoll, capt, D'Arcy, Trimble; O'Gara, Reddan; Horan, Flannery, Hayes, O'Callaghan, O'Connell, Easterby, D Wallace, Leamy.
Replacements: Sheahan, S Best, O'Kelly, N Best, Boss, P Wallace, Duffy.