Fiji have omitted wing Rupeni Caucaunibuca and captain and back-rower Alifereti Doviverata from their World Cup squad.
Caucaunibuca was one of the stars of the 2003 World Cup
France-based star Caucaunibuca is currently serving a doping ban after testing positive for marijuana.
There is also no place for veteran wing Sireli Bobo, Fiji opting for only three specialist wingers in Vilimone Delasau, Isoa Neivua and Filimone Bolavucu.
Doviverata led Fiji at the 2003 Cup and in this year's Pacific Nations Cup.
Caucaunibuca is currently serving a three-month ban after testing positive for the recreational drug, but his sentence had been back-dated, which would have allowed him to be available for Fiji's second World Cup match.
We can defeat Wales as we have got the size up front
Fiji forwards coach Greg Mumm
Caucaunibuca is arguably Fiji's best-known current player in the 15-man version of the game, having thrilled the crowds at the last World Cup with his destructive running.
However, he has made only a handful of appearances for his country since.
In 2005 Caucaunibuca was banned from representing Fiji for a year after failing to show up at the World Cup qualifiers.
Fiji-based fly-half Waisea Luveniyali is included, and at 21 he is the youngest member of the Fiji squad.
He will share the fly-half role in France with veteran Nicky Little, who will be attending his third World Cup.
Doviverata's omission from the back-row comes because the selectors have opted for Sisa Koyamaibole and Aca Ratuva in the number eight role, and awarded the third position to Akapusi Qera.
Fiji coach Ili Tabua opens his campaign against Japan in Toulouse on 12 September, with Australia, Wales and Canada also in the group.
The forwards will now come under the guidance of Australian Greg Mumm, who said Fiji had the ability to upset Wales and Australia.
"Our forwards will be more competitive," Mumm said.
"We can defeat Wales [in Nantes on 29 September] as we have got the size up front and our forwards have got a good height advantage.
"The only thing we need to work on is to improve on the set pieces.
"If Fiji can dominate possession, I'm confident that we can upset Wales and we can also match the Wallabies."
Fiji's World Cup squad: Jone Qovu (back-row, Metro Racing Paris), Isoa Domolailai (lock, Toulon), Bill Gadolo (hooker, Lomaiviti), Jone Railomo (prop, Poitevin), Netani Talei (back-row, Worcester), Alefoso Yalayalatabua (prop, Navy), Semisi Naevo (lock, NEC), Sisa Koyamaibole (back-row, Taranaki), Aca Ratuva (back-row, Massy), Akapusi Qera (back-row, Gloucester), Graham Dewes (prop, Marist), Kele Leawere (lock, Hino Motors), Wame Lewaravu (back-row, Disavu), Sunia Koto (prop/hooker, Marist New Zealand), Henry Qiodravu (prop, Orleans), Ifereimi Rawaqa (lock, World Fighting Bull), Vereniki Sauturaga (hooker, Duavata), Seru Rabeni (centre/wing, Leicester), Seremaia Bai (centre, Clermont-Auvergne), Norman Ligairi (full-back, Brive), Gabiriele Lovobalavu (centre, Marist), Waisea Luveniyali (fly-half, Airport), Jone Daunivucu (half-back, Tarbes), Nicky Little (fly-half, Saracens), Mosese Rauluni (scrum-half, Saracens), Vilimone Delasau (wing, Clermont-Auvergne), Isoa Neivua (wing, Mosimosi), Maleli Kunavore (utility back, Toulouse), Filimone Bolavucu (wing, Brive), Kameli Ratuvou (wing, Saracens)