Clifton wing Danielle Waterman scored a hat-trick of tries to help England maintain their bid for a second straight Six Nations Grand Slam.
Waterman made her debut for England against Ireland in 2003
England dominated the first half with Waterman and Charlotte Barras scoring twice and Maggie Alphonsi adding another to put them 31-0 ahead.
France number eight Delphine Plantet responded just after the break but Waterman added her third on 69 minutes.
Christelle Le Duff added a second score for France with three minutes left.
"I am delighted with this scoreline," said head coach Geoff Richards.
"Before the game I never expected this would be the kind of result we would be looking at.
"We played really well in the first-half and the players did everything asked of them. We scored some decent tries early on which I think stunned France and put them on the back-foot.
"After the break we lost some control, but we kept it together and it was only for a few errors that let France in and they scored."
England will seal the Grand Slam if they can beat Wales at Taffs Well this Saturday.
England: Barras (Saracens); Watermen (Clifton), Allan (Saracens), Burford (Saracens), Day (Wasps), Andrew (Saracens), Turner (Wasps); Clark (Henley), Garnett (Saracens), Storie (Blaydon), Taylor (Thirsk), McGilchrist (Wasps), Stevens (Clifton) Alphonsi (Saracens), Spencer (Worcester).
Replacements: Layland (Richmond), Gray (Wasps), Beale (Leos), Hunter (Lichfield), McLean (Thirsk), Staniford (Wasps), Penrith (Cardiff Quins)
England's remaining Six Nations fixture:
17 Mar: v Wales, 1430 GMT (Taffs Wells RFC)