Young backs Robert Kearney of Leinster and Munster's Barry Murphy are the two uncapped players included in Ireland's squad for the RBS Six Nations campaign.
Barry Murphy and John Kearney are in the Ireland panel
Gordon D'Arcy returns to an almost full-strength squad which is missing only the suspended Alan Quinlan and the injured Stephen Ferris.
Ireland, many people's favourites for the title, also include 83-cap veteran Malcolm O'Kelly.
Celtic League champions Ulster have eight players in the 35-man squad.
In the forwards, Simon Best is joined by his younger brother Rory, namesake Neil Best and prop Bryan Young.
Wingers Tommy Bowe and Andrew Trimble are included alongside half-backs Isaac Boss and Paddy Wallace.
"The championship is a long and hard tournament that will always test your resources, so I felt we needed to increase our squad to 35 to give us some extra cover," said coach Eddie O'Sullivan.
"We have a good injury profile at the moment and with the return of players from injury, such as Tommy Bowe and Jerry Flannery as well as the other additions to the squad, it will push up the competition levels.
"An away trip to play Wales is one of the toughest openings you could get at this moment. We are focusing on is trying to get the right performance."
Ireland squad - forwards: Neil Best, Rory Best, Simon Best, Simon Easterby, Jerry Flannery, Keith Gleeson, John Hayes, Jamie Heaslip, Trevor Hogan, Marcus Horan, Denis Leamy, Donncha O'Callaghan, Paul O'Connell, Mick O'Driscoll, Malcolm O'Kelly, Frankie Sheahan, David Wallace, Bryan Young.
Backs: Isaac Boss, Tommy Bowe, Girvan Dempsey, Gordon D'Arcy, Luke Fitzgerald, Shane Horgan, Denis Hickie, Robert Kearney, John Kelly, Barry Murphy, Geordan Murphy, Brian O'Driscoll, Ronan O'Gara, Eoin Reddan, Peter Stringer, Andrew Trimble, Paddy Wallace.