Wigan centre Kevin Brown will be out for four to six weeks after breaking a bone in his leg against Wakefield.
Brown has impressed this season in the absence of David Hodgson
The 19-year-old, who has played in all but one of the Warriors' 15 games this season, has fractured his fibula.
But Martin Aspinwall should be back from a hamstring injury for Friday's trip to Warrington, while Gary Connolly has returned from Leeds.
"With Kevin Brown being out, Gary's going to be a great asset," said Wigan's assistant coach Denis Betts.
Wigan will have prop forward Danny Sculthorpe back for the third meeting of the season with the Wolves, after missing the win over Wakefield with illness.
Hooker Terry Newton should also return after recovering from bruised ribs.
Betts, who operated with just two specialist props on Sunday, is still waiting to discover if he will be able to play Quentin Pongia against Warrington.
The veteran New Zealander was omitted from the team at the weekend
following revelations that he has Hepatitis B but the authorities are satisfied there is no risk of infection.
"Quentin is training with us and he's in the squad," said Betts. "It will be made a lot clearer to me later in the week whether he's available."
Meanwhile, Wigan head coach Mike Gregory has returned from America, where he
has spent a week having specialist treatment for a chronic bacterial infection.
"I spoke to him this morning and he is in good spirits," Betts added. "He
arrived back safely but his luggage is still in Philadelphia."