St Helens have been at their Knowsley Road home since 1890
St Helens' proposals for a new £25m 18,000-capacity stadium have received the support of local councillors.
The application will turn a derelict 46-acre site that used to house a glass factory into a purpose-built stadium and multi-million pound superstore.
"It's great news for the club and the town," said chairman Eamonn McManus.
Delighted council leader Brian Spencer added: "This has been 10 years in the making but it will be a first-class stadium for a world-class club."
Saints believe a move away from their ageing Knowsley Road ground is essential if they are to maintain their place in Super League from 2012.
The proposal was opposed by a rival supermarket but members of the St Helens council planning committee endorsed the application, subject to terms and conditions and a health and safety risk assessment.
The plans, which will now go forward to regional government for approval, could be the subject of a public inquiry and may yet be threatened by a condition placed on the approval requiring part of the historic site to be preserved.
As part of a separate plan, Knowsley Road - home to Saints for 116 years - will be demolished to make way for housing.