Leeds went to the top of Super League XVI as they made it two wins out of two with victory at the KC Stadium.
First-half tries from Brent Webb, Ryan Hall, Rob Burrow and Ben Jones-Bishop were the cornerstone of the victory.
Beaten by local rivals Hull KR five days ago, Hull stayed in it with the second of two tries from Mark O'Meley.
But Chris Clarkson and debutant Weller Hauraki wrapped up victory before home winger Will Sharp's late effort reduced the arrears.
Leeds have now won all their last seven Super League meetings with Hull.
Victory came at a cost for the visitors, Kiwi full-back Webb limping off after just five minutes, while both Carl Ablett and Brett Delaney also failed to finish the game.
But, after coming back from 28-10 down to
beat Bradford 32-28
with a dramatic last-gasp penalty try at the Millennium Stadium last weekend, Leeds again looked pretty in pink, although this time signalling their intentions with a try after only 103 seconds.
After cashing in on Keith Senior's break, Webb nearly scored twice more, Tom Briscoe and Richard Whiting denying him, before hobbling out of the action.
Hull somehow rallied to level, when Aussie prop O'Meley barged over from close range after a Danny Houghton pass. But the rest of the half belonged to Leeds.
Ablett's fine cut-out pass put in England winger Hall - scorer of seven tries against Hull last season.
Senior's offload then started a move that went through eight pairs of hands before Burrow got try number three.
In Danny Buderus, Rob Burrow and Kevin Sinfield, they had three players who gave us a really good, patient, working over
Hull coach Richard Agar
At that point, following Kevin Sinfield's second goal, Hull were waiting for the half-time whistle but worse was to come when a disappointing kick from the largely anonymous Sean Long was tipped by Sinfield into the hands of Jones-Bishop.
And, with no-one at home in the home defence, the young winger raced almost the length of the field for his fourth try in two games.
Long did not return after the interval because of an Achilles problem, new half-back Sam Obst taking his place. But the Wakefield man's arrival and the loss of Brett Delaney to injury could not halt Leeds' momentum.
Burrow's kick to the corner with 47 minutes gone put the Hull defence in all sorts of trouble, the loose ball falling into the hands of Clarkson, who scooted in to score.
The durable O'Meley went over again for Hull but any fanciful comeback hopes were ended when Hauraki's kick through fell to Danny Buderus, who masterfully returned the ball to the forward to score.
Winter signing Sharp did make it two tries in as many games since joining Hull with 10 minutes to go, but there would be no comeback, especially after Burrow and Sinfield landed drop-goals.
And that put the seal on five straight wins for Leeds at the KC Stadium.
Hull coach Richard Agar:
"A couple of losses is no laughing matter.
"There was no lack of effort on our part, but we lacked that little bit of smartness.
"And, in Danny Buderus, Rob Burrow and Kevin Sinfield, they had three players who gave us a really good, patient, working over."
Leeds coach Brian McDermott: "Brent Webb might not be back next week with a gash on his leg. We thought he'd broken it at first.
"Carl Ablett has twinged a cartilage and Brett Delaney has knackered ligaments on his ankle so they might be weeks.
"We had one substitute in the second half and our three props, Ian Kirke, Luke Burgess and Kylie Leuluai, did a lot of game time and really laid the platform.
"There was some terrific stuff wasn't there? You have to give credit to some of those players. But I don't think it was as polished as the scoreline would suggest."
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