A try in each half from former Wigan prop Jerome Guisset helped France claim their biggest ever win over Wales and clinch the European Nations Cup title.
France: (26) 38
Tries: Charles 2, Rinaldi, Hermet, Guisset 2, Zitter
Goals: Frayssinous 5
Wales: (6) 16
Tries: Hughes 2, Briers
Goals: Briers 2
John Monie's side put in a superb first-half display with Olivier Charles going over for the first of his two tries after two minutes.
France led 26-6 at the break and looked well in control.
Adam Hughes and Lee Briers gave Wales some hope with second-half tries but the French were too strong.
Wales coach Martin Hall was happy with his side's performance despite the loss.
"Our efforts, considering what we were up against, were excellent," he said.
"The French were a solid and well-drilled outfit but, at times, it felt we were up against 14 men.
"In fact, considering we played 60 minutes of the game with 12 men, I think we came out of the came with credit.
"I'd like to thank the Welsh management and players for all their efforts. Everyone has given 100 per cent."
France: Guigue (Catalans), Charles (Villeneuve Sur Lot), Hermet (Villeneuve Sur Lot), Sadaoui (Catalans), Zitter (Barrow), Greseque (Pia), Rinaldi (Catalans), Guisset (Catalans), Berthezene (Catalans), Ferriol (Limoux), Mounis (Catalans), Fakir (Catalans), Moly (Carcassonne).
Replacements: Fellous (Catalans), Carrasco (Villeneuve Sur Lot), Raguin (Toulouse), Frayssinous (Catalans)
Wales: Gibson (Halifax), Powell (Featherstone Rovers), Blackwood (Halifax), Hughes (Widnes), Johnson (Aberavon Fighting Irish), Briers (Warrington, Captain), Lennon (Manly Sea Eagles), Mills (London Broncos), Watson (Swinton), Dean (Carcassonne), Morley (Halifax), James (Castleford), Joseph (Swinton).
Replacements: Karl Hocking (Bridgend Blue Bulls), Byron Smith (Castleford), Gareth Price (Rochdale), Lenny Woodard (Bridgend Blue Bulls), Paul Morgan (Bridgend Blue Bulls).
Referee: Glen Black (NZ)