Wigan scrum-half Luke Robinson scored three tries to ease the Warriors into the Challenge Cup quarter-finals.
Limouxin 20 (4):
Tries: Nelson, Almarcha, Mackie, Grandjean
Cons: Espebenex 2
Wigan 80 (44):
Tries: Robinson 3, Hock 2, Radlinski, Melling, Aspinwall, Brown, Dallas, Orr, Mark Smith, Newton, O'Loughlin
Cons:Melling 10, Orr 2
The Super League side scored 14 tries against the French side who took a shock early lead at Stade Aiguilles.
But four tries in 12 minutes helped the 2002 champions to a 44-4 half-time lead and they continued to run riot in the second half.
Wigan teenager Chris Melling kicked 10 goals and score a try while Limouxin's late rally offered some consolation.
Wigan coach Mike Gregory was happy with his side's comfortable victory.
"It was quite clinical, a team effort, and I was pleased from the first minute to the 80th with the way they got on top and stuck with it."
"The team stuck to a plan, they ripped in around the rucks and made inroads when we decided to play football.
"I was disappointed to let three late tries in but we have to give credit to Limouxin," he said.
Limouxin: Espebenex, Zitter, Pau, Nelson, Almarcha, Filt,
Murciz, Mackie, Leffort, Muliumu, Laurent, Feuniol, Baigaso.
Replacements: Grandjean, Burgot, Mespie, Biraugich.
Wigan: Radlinski, Melling, Aspinwall, Brown, Dallas, Orr,
Robinson, Sculthorpe, Pongia, Newton, Hock, Wild, O'Loughlin.
Replacements: C. Smith, M. Smith, Tickle, O'Connor.
Referee: Karl Kirkpatrick (Warrington)