Leeds (28) 64
Tries: Hall 3, McGuire 2, Jones-Bishop, Ablett, Lauitiiti, Buderus, Peacock, Smith
Goals: Sinfield 10
Wakefield (4) 20
Tries: Tongia, Veivers, Tony, Amor Goals: Moore 2
Ryan Hall brought up his Leeds century of tries in his 119th game for the club
Beaten Challenge Cup finalists Leeds kept up their hopes of a top four finish as they romped to their biggest Super League score of the season.
Ryan Hall's treble led the way, Danny McGuire getting two of their 11 tries.
Leeds soon showed that Wembley was out of their system as Hall (2), Ben Jones-Bishop, Carl Ablett and McGuire ran in five tries before the break.
Ali Lauitiiti, Danny Buderus, Jamie Peacock and Lee Smith also crossed, while Kevin Sinfield kicked 10 goals.
Wakefield's four tries came from Ryan Tongia, Josh Veivers, Motu Tony and Kyle Amor, while Gareth Moore kicked two goals.
Leeds, still counting the cost of last weekend's Challenge Cup final defeat, were without Rob Burrow, Brent Webb and forward Chris Clarkson, and it will take more than thumping a team of strugglers to ease the pain of last weekend's 28-18 defeat by Wigan at Wembley.
But, in claiming the two points they needed to ensure their place in the play-offs, Leeds are back to winning ways.
And, just as in their last home game three weeks ago when they beat Castleford 56-0, the Rhinos again showed signs of their best form just when it matters most.
Leeds, still chasing a top four finish, moved into fifth, putting the pressure on Catalan Dragons, who face Hull KR on Saturday evening and fourth-placed Huddersfield, who host Harlequins on Sunday.
And the night belonged to winger Hall, who claimed a third-minute opener for his 100th Rhinos try, touched down again four minutes before the break and completed his treble with 13 minutes remaining to take his tally to 27 for the season.
Leeds, who claimed a double over their local rivals, having also beaten the Wildcats 28-6 in this season's first meeting at Belle Vue back in March, have now enjoyed five successive home Super League wins over Wakefield.
Defeat for Wakefield, who have now lost their last nine matches, increases the likelihood of them finishing bottom of Super League.
Leeds coach Brian McDermott:
"I was really pleased for the fellahs. They were in a dark place last week and were really determined to do something special tonight. We ran and defended with determination and I thought we could have scored a few more points.
"But, if anyone wants this game to progress to where we all think it should progress to, our attitude towards dominant teams needs to change, because I just thought that was refereed at the lowest common denominator.
"There were 20 occasions when they could have been penalised for holding down. That went on throughout the game and it was almost like 'let's feel sorry for the opposition.' All it did was make it a frustrating second half for everyone.
"It wasn't Ben Thaler's fault as an individual. I just think it's our sport and the governing body and the attitudes, instructions and the edicts that come from above allows people to use spoiling tactics and get away with it."
Wakefield coach John Kear:
"I thought Leeds were very good. There were some big performances from some of our lads but not enough of them.
"Motu Tony, Julien Rinaldi, Glen Morrison and Paul Johnson did well.
"But credit to Leeds. They must have been emotionally and physically down after last week but they did very well."
Leeds: Smith; Jones-Bishop, Hardaker, Ablett, Hall; Sinfield, McGuire; Leuluai, Buderus, Peacock, Jones-Buchanan, Delaney, Hauraki.
Replacements: Bailey, Lauitiiti, Pitts, McShane.
Wakefield: Tony; Morton, Veivers, Tadulala, Tongia; Moore, Lee; Amor, Rinaldi, Higgins, P Johnson, Morrison, Howarth.
Replacements: Gledhill, Wildie, Hickey, Walshaw.
Referee: Ben Thaler (Wakefield).