Huddersfield (18) 29
Tries: Grix, Patrick, Robinson, McGillvary
Goals: Brough 6 Drop-goals: Brough
Warrington (10) 10
Tries: Hodgson 2 Goals: B Hodgson
David Hodgson and Kevin Brown halt Wolves forward Louis Anderson
Huddersfield catapulted to the head of Super League XVI as they ran in four tries to beat Warrington in the battle of the top two at the Galpharm Stadium.
First-half tries from Scott Grix, Larne Patrick and Luke Robinson set the Giants on the way to their second win over Warrington this season.
Brett Hodgson scored all his side's points on his return to Huddersfield.
But Jermaine McGillvary's late try, allied to Danny Brough's 13-point haul with the boot, closed the door.
Huddersfield had already claimed Warrington's scalp this season, having beaten Tony Smith's men 28-18 in the Magic Weekend campaign opener at the Millennium Stadium on 12 February.
Warrington had responded to that by winning six on the spin until being stunned at home by Catalan Dragons last Sunday.
But, without injured chief playmaker Lee Briers, the Wolves' second straight defeat was less of a surprise against a Giants side, orchestrated by Brough, who are really starting to find their form.
Having also beaten Warrington in last season's play-offs, that made it three wins in a row for the Giants over their 2009 Challenge Cup final conquerors.
And, while it put one over former Giants coach Smith, the more telling aspect for opposite number Nathan Brown was that it provides further evidence of his side's genuine title credentials.
Huddersfield took just three minutes to score when Grix got on the end of McGillvary's kick through, Brough adding the extras.
On his return to the Galpharm for the first time since leaving at the end of last season, Hodgson took just five minutes to reply, converting his own try after fellow Aussie Joel Monaghan was twice involved in the move.
But Huddersfield, twice beaten here by Warrington last season (the second of them a 60-4 Challenge Cup hammering in May) bounced back to go two scores clear by the break.
To keep Warrington to 10 points is something to be really proud of
Huddersfield Giants coach Nathan Brown
After a superb tackle by Brough forced Hodgson to ground the ball back behind his own line, the Giants kept up the pressure sufficiently for Robinson to send Patrick in for their second try.
And after Brough added that conversion, there was more to come when Robinson sneaked over seven minutes before the break.
Hodgson reduced the gap, when, latching onto Richie Myler's pass just before the interval, he was adjudged to have got away with what might easily have been construed a double movement, the video referee ruling in Warrington's favour.
But the Aussie full-back for once missed with his kick from the touchline to leave the visitors eight points adrift at the break.
Brough then added to that, twice kicking penalties to stretch his side into a 22-10 lead going into the final quarter.
Brough's drop goal 17 minutes from time effectively sealed Warrington's second straight defeat.
But, after losing prop Andy Raleigh following a late high tackle that left him with an accidental eye injury, there was still time for the Giants to rub salt in the wounds when McGillvary added the home side's fourth try.
Huddersfield coach Nathan Brown:
"We're happy with how we're ticking over. To keep Warrington to 10 points is something to be really proud of.
"From an attacking point of view, we didn't start the second half that well but to get a win like that, the guys should be very happy.
"Luke O'Donnell is probably the buy of the year. He's a terrific player."
Warrington coach Tony Smith:
"They were very good. They out-enthused us. Technically, they were a lot better than us in a lot of areas. Our completion rate was atrocious. We didn't build a game until the last five or 10 minutes of the first half.
"When you give the Giants a start like that, it's hard to claw it back. They are a very good team and deserve to be where they are at the moment.
"We've got a few players not in their best form. They've had a dip in form, some more than others. But the people on the field were good enough to win and we didn't do that, down mainly to the opposition."
Huddersfield: Grix; McGillvary, Cudjoe, Lawrence, Simpson; Brown, Brough; Crabtree, Robinson, Raleigh, Gilmour, Ferguson, O'Donnell.
Replacements: Lunt, Faiumu, Patrick, Kirmond.
Warrington: Hodgson; J Monaghan, Blythe, Atkins, Evans; Bridge, Myler; Morley, M Monaghan, Carvell, Anderson, Westwood, Harrison.
Replacements: Clarke, Wood, Cooper, Solomona.
Referee: Richard Silverwood (Dewsbury).