O'Loughlin will also miss the play-offs
England have suffered another World Cup blow with the news that Wigan's Sean O'Loughlin has been ruled out after failing to overcome a shoulder injury.
The forward made an abortive comeback six weeks ago after breaking a shoulder blade in May and scans have revealed the bone has still not fully healed.
"He will not be ready for the World Cup which is another blow for England and for him," said Wigan coach Brian Noble.
England coach Tony Smith is already without Bradford prop Sam Burgess.
The Bulls teenager will miss the competition, which begins on 26 October, to undergo shoulder surgery.
O'Loughlin's injury is also a setback for Wigan ahead of the Super League play-offs.
"It's a shame for the lad but clearly he now needs to rest it for at least four weeks before he can start training again," added Noble.