St Helens duo Martin Gleeson and Sean Long have been banned for four and three months respectively for breaking rugby league betting rules.
Gleeson played in the match in question
The pair both admitted placing bets on Saints to lose their Super League match with Bradford on Easter Monday.
Gleeson, who played in the match, is suspended until 17 October, with Long banned until 17 September, both with immediate effect.
Both players were also fined £7,500 and ordered to pay costs of £2,205 each.
The suspensions, handed out by a Rugby Football League disciplinary panel on Thursday, are a major blow for St Helens.
Coach Ian Millward will be deprived of two key players as Saints try to add the Super League crown to last month's Challenge Cup triumph.
Long would be free to return for the play-offs, although Gleeson's season is effectively over and he would miss the Grand Final on 16 October if Saints qualify.
Millward surprisingly left out 11 first-team players for the game, which the Bulls won 54-8.
Gleeson played and scored the opening try, but Long was left out due to injury.
Allegations of betting irregularities against the two players surfaced in the days following the game and a RFL investigation ruled both had a case to answer.
The pair both won around £900 and pleaded guilty to charges of misconduct at a four-hour hearing.
Long missed the match with injury
The hearing learnt that Gleeson opened an account with an offshore bookmaker at
4.30pm the day before the match.
He later placed a bet of £1,000 to win £900 on Bradford beating Saints by more than eight points.
Long opened his account at 6.19pm on the same day and placed a bet of £600 and
20 minutes later staked a further £400.
Both players admitted guilt and apologised for their actions but claimed they were unaware of an RFL by-law prohibiting betting on matches in which their club was involved.
Long initially said he he had placed the bet for a friend but an investigation revealed that both players placed their winnings in their own bank accounts.
The rulings were made by a panel comprising Judge Peter Charlesworth, Deryck
Fox and David Poulter.
A statement read: "We regard the case of Martin Gleeson as the more serious
because he played in the game and was in a position to affect the outcome
"The adverse publicity for the RFL and the sport when these bets were exposed
has been immense.
"It brings into question the integrity of the game and the perception of the
sport by the general public, let alone the supporters of the team who were
entitled to expect their players to seek only the success of their side and not
to obtain a personal profit by losing.
"There must be a significant penalty in order to fulfil our duty to preserve the good name of rugby league. We are also conscious that we are setting a precedent."