Boston's defence of their World Series crown got off to the worst possible start with a 9-2 defeat to their arch-rivals, the New York Yankees.
Matsui blasts off the Yankees' season
Hideki Matsui had three hits for the Yankees, including a home run.
Pitcher Randy Johnson, making his New York debut, allowed one run on five hits in six innings.
The Red Sox beat the Yankees to win the American League pennant last October before going on to win their first World Series since 1918.
Matsui hit the first home run of the new Major League season in the eighth inning off Matt Mantei.
He finished 3-for-5 with three RBI and made a fantastic catch to deprive Kevin Miller of a two-run homer in the third inning.
It was a miserable return to the Yankee Stadium for former New York player David Wells, who allowed four runs for 10 hits in just over four innings.
Johnson, who joined the Yankees from the Arizona Diamondbacks in January, said he was pleased to get his first appearance at Yankee Stadium out of the way.
"It was nice to get a feeling of the way it's going
to be here," said Johnson.
"Tonight's not going to be indicative of the way it's going to be every time I pitch, but I got it out of the way. It was a real nice effort by everybody."
Left-hander Johnson led the major leagues last year with 290
strikeouts, with a 2.60 earned run average.