Nomar Garciaparra managed a base hit in his first game of the season but it was not enough to save Boston Red Sox from an 8-1 defeat to San Diego Padres.
The All-Star shortstop, who missed the first 57 games with Achilles tendonitis, was substituted later in the game, after a rain delay lasting two hours 21 minutes.
Brian Lawrence pitched five scoreless innings for the visitors, while Khalil Greene had three hits and a pair of RBIs.
Derek Jeter returned from a three-game absence to hit a homer in the seventh inning and lead
the New York Yankees back from a 5-0 deficit to a 7-5 win over Colorado Rockies.
Jeter, who had been sidelined by tightness in his left groin, Bernie Williams and Gary Sheffield all hit over the fence as New York recorded their 12th straight win in an inter-league game.
In Wednesday's only National League game, Jim Edmonds homered twice and drove in four runs and Edgar Renteria hit a grand slam, pacing the St Louis Cardinals to a 12-4 win over Chicago Cubs.
In his second start of the season after Achilles and elbow trouble, the Cubs' All-Star pitcher Mark Prior was hit hard, allowing five runs on five hits in less than four innings.