Prix de l'Arc de Triomphe
Venue: Longchamp, Paris Date: Sunday, 5 October at 1540 BST
Coverage: Live on BBC Two 1300-1600 BST. Commentary on BBC Radio 5 Live
Unbeaten Zarkava won June's 'Le Prix de Diane' in Chantilly, France
Epsom Oaks winner Look Here will miss the Prix de l'Arc de Triomphe at Longchamp on Sunday.
The filly's trainer Ralph Beckett was not satisfied with a blood sample taken ahead of the Group One contest.
German Derby winner Kamsin has been supplemented to the field for the £4m contest, the world's richest turf race.
Unbeaten filly Zarkava is the favourite to win the contest, for which 17 horses stood their ground on Thursday.
If the French horse extends her winning streak to seven, she would become the first filly since Urban Sea in 1993 to win Europe's most prestigious race.
There were no major surprises at Thursday's supplementary stage.
"The Aidan O'Brien-trained duo of Septimus and King Of Rome were taken out, leaving Duke Of Marmalade and Soldier Of Fortune to spearhead the Ballydoyle attack.
Outsider Normen was the other horse removed from the race.
Beckett said Look Here, a daughter of Hernando, may not run again in 2008.
"Look Here will not be supplemented for the race. We had to run all the tests on her and we were not happy with her blood sample." he said.
"She looks fantastic and we have been happy with her work but you have got to be in top order for a race like the Arc so she will not run at the weekend."