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Video - Pistorius victorious in 200m
British duo Ian Jones and Hazel Simpson won bronze medals in their 200m finals.
Jones finished behind "Blade Runner" Oscar Pistorius, who powered to victory in the T44 final with a Paralympic record of 21.67 seconds.
The South African claimed the sprint double after winning the T44 100m on Tuesday and the 21-year-old will now go for gold in the 400m event.
Simpson, who won two silvers in Athens, finished in 32.43 seconds behind Wang Fangnd Claudia Nicoleitzic.
The 29-year-old was relieved to secure a podium finish after tiring towards the end of her race.
"I had to really grit my teeth and run all the way through the line. I nearly crushed my teeth," said Simpson.
Elsewhere Martin Crutchley finished fifth in the F37/F38 shot put final, with a best throw of 12.72 metres.
Nathan Stephens finished 11th in the F57/58 discus final, but maintains strong medal hopes in the javelin on Tuesday.
In the women's T37 200m semi-final Katrina Hart finished fourth, setting a season's best of 31.24 seconds, while Shelley Woods finished third in her T54 800m semi-final with a time of 55.52 seconds. Both will compete in Sunday's finals.
Wheelchair racer Mickey Bushell broke the British record to finish sixth in his T53 200m semi-final, but unfortunately his performance was not good enough to progress into the final.