Paralympian Nyree Lewis led the way with new World and European records at the Nationwide Open Long Course Swimming Championships in Sheffield.
Lewis was among the medallists at the Athens Paralympics
Lewis beat her own world best in the S6 100m backstroke by 0.84 seconds for a time of one minute 27.81 seconds.
She also beat Mhairi Love's European record in the S6 400m freestyle in a new time of 6:00.08.
Both marks are subject to ratification from the International Paralympic Committee.
Lewis' partner Sascha Kindred knocked 0.19 seconds off his own SB7 100m world breaststroke record with a new time of 1:22.98.
Chris Pugh beat compatriot Francis Dart's old world record in the S14 400m freestyle with 4:24.12.
The weekend's event gave swimmers a first chance to set times to clinch their places on the Great Britain team for December's World Championships in South Africa.
A total of 14 male and 14 female swimmers achieved the qualifying times for the event.
Swimmers will have a second chance to make the times at next month's ASA long course event at the same pool.
The team for South Africa will be announced on 8 August.