Armstrong broke his collarbone during the Vuelta Castilla y Leon in March
Lance Armstrong will make his comeback from his collarbone injury in the Tour de Gila in New Mexico on 29 April.
The race, which runs over five days, will give the American the chance to find some form ahead of the Giro d'Italia, which begins on 9 May.
Armstrong, who was injured in a crash in Spain last month, has been on a 10-day training programme in Colorado.
The Astana team rider will race on an individual basis due to International Cycling Union (UCI) regulations.
Astana team spokesman Philippe Maertens said: "Lance is currently flying back to Colorado but will head out to New Mexico straight after.
"Racing in New Mexico is ideal as far as preparations for the Giro d'Italia go.
"Lance was originally scheduled to race at the Tour de Trentino but that finished last week.
"This way he goes into the Giro not long after competing."
Armstrong wrote on his Twitter feed on Tuesday: "Cycling fans - got word early today that we can race the Tour of Gila. Great news. Flying to Silver City, NM tonight."
The seven-time Tour de France champion broke his collarbone during the Vuelta of Castilla and Leon in Spain on 23 March and had surgery two days later.
A stainless steel plate and 12 screws were inserted to stabilise it.
Race director Jack Brennan revealed that Armstrong and Astana team-mates Levi Leipheimer and Chris Horner will be allowed to compete after US Cycling reached an agreement with the UCI.
Normally teams like Astana are not allowed to compete in national-level events, such as the Tour de Gila, but a compromise will allow three members of the professional team to race individually without a team car or team director.