Pujols (centre) leaves the game after his injury
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St Louis Cardinals slugger Albert Pujols could be out of action for several weeks after straining a muscle.
Pujols, who leads the major leagues in home runs (25) and RBI (65), pulled up and grabbed his right side after chasing a foul ball by Aramis Ramirez.
"He's going to miss a significant period of time," said St Louis manager Tony LaRussa of his star first baseman.
"If you told me right now he'd be out two weeks, I'd buy you dinner the rest of the year."
Pujols' injury put the seal on a bad day for the Cardinals who lost 8-5 at home to the Chicago Cubs.
Aramis Ramirez hit a grand slam home run and Phil Nevin hit a two-run homer in his first start for the Cubs.