"We would like to feed that passion," added Goodell.
"There have been discussions [about] a second game in another UK market - that's something that we'll evaluate."
The 74,000-capacity Millennium Stadium has previously hosted FA Cup and League Cup finals, the Rugby World Cup final, the Rugby League Challenge Cup final and is home to Wales' national rugby and soccer teams.
Wembley beat off competition from the Millennium Stadium and Murrayfield to stage the one current NFL fixture outside the United States.
But now the Cardiff arena is hoping for a second chance as the Millennium Stadium's head of marketing Gwyn Dolphin admitted: "The Millennium Stadium and NFL have held discussions for some time.
"The news that the National Football League is looking to stage an additional event in the UK is an attractive prospect for all fans of the sport.
"The discussions are a result of our ability to attract the biggest and the best to the Millennium Stadium."
Goodell said there are no plans to play a Super Bowl in London, but added a second regular-season game was drawing support from league owners.
"I think the teams that have gone over [to London] have had a great experience," he said.
"We've been able to build on that, and I think teams recognise it's an honour and a privilege to play there. And it can be done without impacting them negatively."
However, some players have been critical of the overseas game because of the extensive travel involved in the middle of the season.
One team also loses a home fixture in the arrangement.
"The negative is taking the home game away from the fans," Goodell admitted.
"It's another reason why potentially restructuring the season and changing two pre-season (games) into regular-season (games) can be something that is beneficial to the fans."
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