Over half a million people applied for tickets for last year's clash at Wembley
The NFL has had "substantive talks" with officials in London about holding the Super Bowl in the city, a senior league official has told BBC Sport.
While commissioner Roger Goodell has previously admitted an interest in bringing the game to London, this is the first confirmation of discussions.
"We've spoken on what it would take to host and for us to bring it over," said events vice-president Frank Supovitz.
"The city has all the facilities needed, and in great quantity."
Supovitz was talking in New York City where the NFL Draft will take place this weekend.
"We have had very substantive conversations with the city of London. We've got to the point of exploring the bid document," he added.
I don't think it's an unrealistic prospect at all
Mark Waller, NFL Head of Sales
Visit London, the capital's official visitor organisation, confirmed that it was pursuing a long-term ambition to bring the Super Bowl to the city.
"Ever since the NFL began playing games in London we have been in discussions with the NFL about what is involved in staging Super Bowl from the host city perspective," said commercial director David Hornby.
"It continues to be something we discuss on a regular basis, without there being any specific timetable or plan in place."
The venues for the next three Super Bowls have already been decided with Dolphin Stadium in Florida, Dallas Cowboys Stadium in Texas and the Lucas Oil Stadium in Indiana putting together successful bids.
But London has become the focal point for the NFL's desire to expand the sport globally, and bringing the sport's showpiece event to the city appears to be a real possibility.
Mark Waller, NFL Head of Sales and Marketing, said: "The NFL is a global property, has a global audience, and London is an incredible city from a sports fan's perspective. I don't think it's an unrealistic prospect at all."
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