The Pittsburgh Steelers will aim to win their sixth Super Bowl title in Tampa Bay on Sunday, while the Arizona Cardinals are appearing in the big game for the first time.
Pittsburgh were the one of the strongest teams during the regular season.
And, even though Arizona have upset the odds to beat three favoured teams during the play-offs, bookmakers expect the Steelers to win by around seven points.
But Rod Woodson, who played for the Steelers for 10 years, won the Super Bowl with Baltimore in 2001 and is an analyst in the BBC TV studio this year, expects the match-up to be closer.
Speaking to Martin Gough, he gives BBC Sport the low-down on how Super Bowl XLIII will be won.
Watch the Super Bowl live from Tampa, Florida from 2300 GMT on BBC One and the BBC Sport website (UK only).
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