The Washington Redskins beat the Philadelphia Eagles 20-12 on Monday, inspired by quarterback Jason Campbell.
Campbell is in his third year as a quarterback for the Redskins
He converted several big plays and was helped by Clinton Portis and Chris Cooley, who both scored touchdowns to keep a 2-0 start to the season.
On Sunday, the New England Patriots put a week of controversy behind them to beat the San Diego Chargers 38-14.
Patriots coach Bill Belichick was fined $500,000 (£249,800) for recording opposing coaches' signals on video.
He will also suffer from the loss of a 2008 draft pick but that had little effect on the team as quarterback Tom Brady threw three touchdowns in front of a loyal crowd.
Elsewhere Green Bay quarterback Brett Favre posted a NFL win record to help secure a win over New York Giants.
The Packers 35-13 triumph was Favre's 149th win as a quarterback which broke the milestone he shared with former Denver Bronco's quarterback John Elway.
"Maybe one day down the road it will mean a lot," Favre said.
"But the most important game is the next game. I'm proud to have played in a lot of games."
The Giants led 10-7 at half-time but Favre took over in the second half, throwing three touchdown passes and finishing 29-of-38 for 286 yards.
The three touchdowns give Favre 417 for his career, leaving him just three shy of former Miami Dolphin Dan Marino's record.
Packers coach Mike McCarthy said: "The all-time anything in this league is such a monumental achievement. One hundred forty nine wins speak for itself."
In other matches the Cleveland Browns recorded a huge 51-45 victory over the Cincinnati Bengals.
It marked just the third game in NFL history that two teams combined for 11 or more touchdown passes.
In Pittsburgh, Ben Roethlisberger threw for 242 yards and a touchdown as the Pittsburgh Steelers defeated the Buffalo Bills 26-3.
And the Super Bowl champions Indianapolis Colts held off the Tennessee Titans 22-20, with quarterback Peyton Manning passing for 312 yards and a touchdown.