Roethlisberger has been out injured
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Ben Roethlisberger threw two touchdown passes on his return from knee injury, leading the Pittsburgh Steelers to a 27-13 win over the Cincinnati Bengals.
Despite a record Cincinnati crowd of 66,104, the Steelers' defence and running game wore the Bengals down.
Roethlisberger attempted just 14 passes and completed nine for 93 yards, but found Heath Miller and Hines Ward on short scoring passes.
Carson Palmer threw for 227 yards and scored the Bengals' lone touchdown.
In Chicago, Thomas Jones rushed for 138 yards to lead the Bears to a 10-6 victory over the Baltimore Ravens.
The Bears improved to 3-3 as their stingy defence kept them in the game, holding the Ravens to just 199 yards of offence.
Meanwhile, Edgerrin James rushed for 139 yards and two touchdowns as the Indianapolis Colts stayed unbeaten with a 38-20 win over the Houston Texans.
Peyton Manning threw for 237 yards and two touchdowns as the Colts scored 24 consecutive points in the second half to break a 14-14 tie.
In Friday's game, the Kansas City Chiefs came up with a smash-and-grab raid to beat Miami Dolphins 30-20 before Hurricane Wilma hits the Florida coast.
Originally scheduled for Sunday, the contest was brought forward two days due to the impending hurricane.
The Chiefs flew to Miami on Friday, becoming the first team in NFL history to travel and play on the same day.
It was the third time the Dolphins have been forced to change a game due to a hurricane and they have lost all three.