Cheyenne Woods, Tiger's 18-year-old niece, made her LPGA debut on Thursday, shooting a three-over-par 75 in Rochester, New York.
She is the daughter of Earl Woods junior, Tiger's half-brother through Earl senior's previous marriage.
Playing on a sponsor's exemption, Woods birdied the second hole, ending her first round in a tie for 121st place.
"I was a little nervous warming up and getting ready but as I teed off my stomach got a little better," she said.
Woods trails leader Sandra Gal from Germany by 11 strokes in the Wegmans tournament and revealed she had received no special pep talk from her famous uncle.
"I talked to him about a month and a half ago when I got the exemption and he was really excited for me to be playing in this. He was just excited and looking forward to how I would do."
According to the New York Times, quoting the LPGA website, only three African-Americans have held a tour playing card, and none since LaRee Sugg in 2000.