Retief Goosen says Gary Player should name names after claiming he knows of golfers on performance-boosting drugs.
Goosen said Player's comments are damaging for golf's image
The two-time US Open winner said he was "very shocked" by his fellow South African's outburst on the eve of the Open Championship at Carnoustie.
"I respect Gary, he's a good friend of mine, but I don't know what he was trying to prove, saying what he said," Goosen said after his first round.
"He mustn't say these half-comments. He might as well not have said anything."
And compatriot Ernie Els rejected claims that drugs are being used in the sport.
"I believe golf is clean," he said. "I don't think taking any kind of drugs will make you play better.
"For Gary Player to say this he must know something but you'll have to ask him. The only way to find out is to start testing but it's unfortunate it's come to this."
Australian Rod Pampling echoed Goosen's called for Player to name names.
"If he's definite he should name the people," said the Australian after his opening round at Carnoustie.
I don't know if he is trying to damage the sport, damage golf
Retief Goosen on Gary Player's drug claims
"I think you have to name the people if you want to make it a worthy statement.
"I haven't seen anyone (using drugs), so I don't know who he's talking about. We'll have to wait and see if he names someone."
Player caused a sensation on Wednesday with his comments.
"I know for a fact that, whether it's HGH (human growth hormone) or steroids, some golfers are doing it," he told the media.
"I would say there's 10 guys taking something. I might be way out - definitely not going to be lower, but might be a hell of a lot more."
England's David Howell added: "I was amazed by the comments. If there was one person (taking drugs) I would be amazed. I'm shocked by his comments, but maybe I am naive.
"It's not even on the radar. I could be absolutely wrong, but of the people I know, no chance. I don't think we have a problem."
Six-time major winner and Ryder Cup captain Nick Faldo was also surprised by Player's comments.
"I know of nobody and have not heard of anyone," he said. "We have an official body to look into that so we will see."