Wie has been hampered by a wrist injury since January
-5 A Park (Bra)
-3 JY Shin (Kor), A Hung (Tha), J Granada (Par)
-1 M Pressel (US)
Level C Matthew (Sco), L Ochoa (Mex)
+5 A Sorenstam (Swe), L Davis (Eng), B Morgan (Wal)
Michelle Wie withdrew from the US Women's Open with a recurrence of her wrist injury midway through her second round at Pines Needles.
The Hawaiian teenager, who carded an opening 82, was six over before quitting on her 10th hole.
Brazil's Angela Park led by two shots on completion of the rain-hit second round on Saturday.
"The last thing I want to do is withdraw, but it left me with no choice," said Wie, 17.
"I just kind of woke up, and it was really sore. It held up but then I tweaked it. And then after that it went downhill.
"I don't remember hurting this much. Now I'll have to re-evaluate. I don't want this to happen again."
Wie, who will travel to Florida for medical advice, first experienced the wrist problem in January.
She was forced to pull out of an LPGA tournament in South Carolina last month when she was 14 over par for 16 holes.
Wie, who has struggled for form this season, has five top-five finishes in majors and finished joint third in this championship last year.
She made the cut at another of the majors, the LPGA Championship, in Maryland earlier this month, but then shot 83 and 79 and finished last of the qualifiers.
Park carded 69 for five under to lead Korea's Ji-Yai Shin, Thailand's Amy Hung and Paraguay's Julieta Granada by two with American Morgan Pressel two shots further back.
Scotland's Catriona Matthew was in a group another shot adrift alongside world number one Lorena Ochoa of Mexico, while Annika Sorenstam ended five over alongside England's Laura Davies and Wales' Becky Morgan.
American 12-year-old Alexis Thompson, the Open's youngest ever qualifier, missed the cut in North Carolina after carding rounds of 76 and 82 for 16 over.
"I saw what I have to be, what my game has to be like," she said. "So I'm going to work on that - I'm going to work on everything - but it was an awesome experience."
The first round was delayed overnight because of thunder and lightning, and only 24 players managed to complete the second round on Friday.