Scotland's Colin Montgomerie missed the Open cut after his second round fell apart down the back nine at Hoylake.
Montgomerie is one of many big names to miss the weekend
Montgomerie had three bogeys and one double-bogey in his last six holes for a 75 and four over for the tournament.
Ryder Cup stars Padraig Harrington, Darren Clarke and David Howell also failed to make the cut.
Robert Rock (69) leads the British and Irish challenge on six under, six off the lead, but Graeme McDowell, Anthony Wall and Greg Owen all shot 73s.
Harrington added a 74 to his first-round 75 as he finished five over while Howell, the European Order of Merit leader, will miss the weekend after a 76 left him on six over.
Harrington, who shot a double-bogey, five bogeys and five birdies, said: "I was tired and I made a lot of poor decisions.
"I have pushed myself the last few weeks and I am still feeling the effects of doing that."
Clarke looked in good form during his 69 on Thursday but two double-bogeys and seven bogeys left him with a dismal second-round 82 and seven over.
He will now take a break from the game to care for his wife Heather, who is battling cancer.
Nick Faldo (71) and Nick Dougherty (73) missed the cut after finishing on four and three over respectively.
Ireland's Paul McGinley just missed out after a second-round 73 left him in joint 71st at level par, with only the top 70 and ties making the weekend.
The 1999 champion Paul Lawrie of Scotland also goes home after a 74 left him six over while Ian Poulter finished on seven over after a dismal 76.
But Lee Westwood (72) is three under going into the weekend, while compatriots Luke Donald (68), Paul Casey (70), John Bickerton (70) and Simon Khan (72) are all two under.
Hopefully Tiger Woods isn't too far ahead and I will have a chance at the weekend
England's Owen, five under overnight, double-bogeyed the par-five 18th to finish on four under, and revealed that conditions had got harder throughout the day.
"They have got some flags right up at the top of the slopes. It was very hard out there, the wind was blowing and I didn't play well on the back nine.
"To finish with a seven hurts. I took a wild swing, the wind got hold of it and it bounced out of bounds," he told BBC Sport.
McDowell was disappointed with his 73 but feels he is playing well enough to get back into contention.
"Hopefully Tiger Woods isn't too far ahead and I will have a chance at the weekend," he told BBC Sport.
"The pressure will be off me and I feel I am playing well enough to get back into it.
"I'm playing some good golf but I was cold with the putter today."
Rock, who came through a qualifying play-off to reach the Open, started terribly with three bogeys in a row from the second hole to slip back to level par but an eagle and four birdies powered him up the leaderboard.
"I was starting to panic after going back to level par. I started thinking about the cut but I got a birdie and got going again," the 29-year-old told BBC Sport.
Donald said he made too many mistakes in his round.
"I tried to play a little more cautiously but still hit fairway bunkers on the 1st and 17th. You try to take them on and get a little greedy and it gets you.
"There are birdies to be had and I had my fair share but I just too many mistakes," he said.