Tiger Woods missed his first cut at a major as a professional after a second straight 76 at Winged Foot on Friday.
Woods played all four rounds of the previous 39 majors he competed in
The world number one finished on 12 over, 13 shots behind Steve Stricker's lead and three shots off the cut mark.
He is not the only big name going home early - Michael Campbell, Sergio Garcia and Retief Goosen missed the cut too.
The top 60 and ties, plus any player within 10 of the lead, qualifies for the weekend at the US Open which means 93 of the 156-strong field missed out.
Campbell, the defending champion, added a 77 to his first-round 75 to join Woods on 12 over, while Spain's Garcia, the world number eight, posted two 78s to be 16 over.
World number four Goosen, a two-time US Open champion, slumped to 15 over after an eight-over 78.
"We just really struggled on the greens today," said the 37-year-old Campbell, who played alongside Woods.
There are a lot of US Opens to go in my career - I'll put this behind me
"Your play gets magnified out there. I didn't play that badly, I just missed a few fairways. Once you do that, you have to chip out sideways and make bogeys."
Despite his disappointment at being unable to defend the title he won so memorably at Pinehurst last year, the New Zealander remained philosophical about his experience this week.
"That's life. You must carry on," he said. "There are a lot of US Opens to go in my career, so I'm looking forward to that. I'll put this behind me."
Ironically, the last player to win the US Open and then miss the cut the following year was Goosen, in 2002.
Another leading light not staying for the weekend is Davis Love III, who won the USPGA at this course in 1997.
But the big story of the day, if not the season, is undoubtedly Woods' failure to make the cut.
The 30-year-old American looked out-of-sorts all week in his first event back after a nine-week break following the death of his father.
Woods has been relatively inaccurate off the tee for some time but has usually been able to get himself out of difficulty with the quality of his iron play and rock-solid putting.
Marginal shots are just getting killed here, more so than any other US Open course we play
But this is not the tournament for great escapes and Woods' waywardness from the tee continually led to problems on the greens.
Woods, who shares the record of 39 consecutive cuts in majors with Jack Nicklaus, parred his first four holes on Friday before double-bogeying the 14th and 16th, his fifth and seventh holes.
He birdied the 17th, his eighth, but there were three more bogeys coming home, including back-to-back dropped shots at his last two holes.
The 10-time major champion hit only seven of 28 fairways over the two rounds and only 18 of 36 greens in regulation.
"I thought I was playing well enough to shoot under par today and I didn't do that," a disconsolate Woods said afterwards.
"It's not rust. Unfortunately I didn't put it together at the right time. I couldn't put it together properly and shot six over.
"I felt like if I kept plodding along I could have turned it around with just one shot. I made two good saves on 18 and one and made another good save on three.
"It's playing hard. The golf course is very difficult, the wind is up now and marginal shots are just getting killed here, more so than any other US Open course we play."
The only cut Woods has ever missed at a major before came at the 1996 Masters when he was still an amateur.
Asked how he would respond to his US Open setback, Woods replied: "Practice. Hopefully I can win the British Open."