Michelle Wie has accepted an invitation to play at the men's European Masters in the Swiss Alps in September.
Wie made her first cut in a men's event earlier this month
It will be the 16-year-old American's debut on the men's European Tour.
England's Laura Davies, who played the ANZ Championship in 2004, is the only other woman to take on the men in a European Tour event.
The big-hitting Wie has played eight men's tournaments so far and made her first cut at the SK Telecom Open in South Korea earlier this month.
She eventually finished tied for 35th place after a disappointing final round of 74.
Wie played her first European golf at the 2004 Curtis Cup at Formby before playing at the Women's British Open at Royal Birkdale as an amateur last year.
The teenager, who is attempting to qualify for next month's US Open on Monday, has opted to play in the European Masters through her association with the event's sponsors, Omega.
"I am honoured to play in my first European Tour event. I am very happy that Omega have extended this invitation and I am very excited to play against the best professional golfers in Europe," said Wie.
Wie has already claimed three top-five finishes in women's majors, including this season's Kraft Nabisco Championship, where she missed being in a play-off by just one shot.
George O'Grady, the tour's executive director, said: "Michelle Wie has demonstrated her outstanding golfing skills to a global audience as both an amateur and now as a professional and we look forward to welcoming her."
The European Masters begins on 7 September in Crans-sur-Sierre in the Swiss Alps.