Highlights - Mexico 0-1 Uruguay
Mexico coach Javier Aguirre is eyeing a potential last-16 clash with Argentina after sealing qualification from Group A despite a 1-0 defeat to Uruguay.
Argentina beat Greece 2-0 on Tuesday to set up a meeting with Mexico in the first knockout round in a repeat of their encounter in Germany in 2006.
Argentina won that game in Leipzig 2-1 after extra time.
"This could be a nice opportunity to take revenge for what happened four years ago," said Aguirre.
Mexico succumbed to a 1-0 defeat by Uruguay in their final group game in Rustenburg, with Ajax striker Luis Suarez heading the only goal late in the first half.
Despite the loss Mexico qualified due to their superior goal difference over hosts South Africa, who beat France 2-1 in Group A's other game.
With both Mexico and Uruguay only needing a draw to progress, there had been fears that the game in Rustenburg would see a repeat of the 1982 World Cup game when Germany and Austria played out a 0-0 draw to send them through on goal difference at Algeria's expense.
"Uruguay played well and Fifa can rest assured that we indeed wanted to win," said Aguirre. "We were not striving for a draw, we played to win and we were faithful to our style."
"We had a lot of the ball but they are very good at locking up and waiting for you to make errors," added Aguirre.
But Mexico captain Rafael Marquez admitted the side must improve if they are to progress further in the tournament.
"We have to get better whatever happens... in terms of what lies ahead, everything is down to us and we have to continue with the good work and try to do what we did against France [who they beat 2-0]," he said.