Arsenal defeated Everton 2-0 to reach the quarter-finals of the FA Women's Cup with England's Rachel Yankey and Katie Chapman scoring the goals.
The defeat means Everton, who beat the Gunners in last season's final, are out of contention for a Champions League place via domestic competition.
Everton's only hope of taking part is by winning this season's Champions League tournament.
The Toffees will face Duisburg in the quarter-final first leg on Thursday.
On Sunday, the deadlock in a hard-fought game was broken when Yankey took advantage of a 57th-minute defensive error to place a low shot into the far corner of the net.
Revenge for the Gunners was wrapped up 16 minutes from time, when Chapman sent a 20-yard lob just under the crossbar.
While the blue half of Merseyside had a disappointing day, the red half was celebrating after Liverpool's 5-0 victory over Charlton Athletic.
Ruesha Littlejohn scored the fifth round's only hat-trick as the Reds ran out comfortable winners against the Southern Division Addicks. Katie Brusell and Suzanne Lappin were Liverpool's other scorers.
On a day of fifth-round shocks, four Women's Super League clubs were eliminated from the competition.
Despite some big-name signings, Birmingham City were humbled by the Premier League's bottom-of-the-table team, losing 2-1 at home to Barnet. Meanwhile, Sunderland won 1-0 against Lincoln.
Lincoln dominated the opening half and striker Carla Cantrell was twice unlucky with shots that hit the woodwork. But the Black Cats made the most of their good fortune as Sophie Williams grabbed the game's only goal 19 minutes from time.
Meanwhile, Birmingham bossed the first half against Barnet and led at the interval through Emily Westwood's 23rd-minute goal.
But the Bees began buzzing at the start of the second half and after Davina Smith's 50th minute equaliser Stacey Sowden hit the 53rd minute winner.
Chelsea, with home advantage, were favourites to win their all-WSL clash against Doncaster Belles but the visitors went through with a 1-0 victory when Vicky Exley fired home a 21st minute long-range free-kick.
The four WSL teams in the quarter-finals will be Arsenal, Liverpool, Doncaster and Bristol Academy, who hammered Sheffield Wednesday 8-0.
The Academy girls passed their Wednesday test with flying honours, the Super League team proving far too strong for Northern Combination opposition.
Ann Marie-Heatherson, Helen Bleazard and Jessica Fishlock each scored two goals and there was one apiece for Lauran Dykes and Molly Clark.
Millwall Lionesses produced their most clinical performance of the season to knock out Premier League rivals Watford 5-0.
Emma Beckett hit the first two goals, the opener a penalty, then Danielle Puddefoot bagged a brace before Kate Longhurst completed the scoring.
In the other fifth-round match, West Ham won through against Enfield Town but it took a Joanne Woodgates goal two minutes from time to beat their plucky South East Combination opponents.
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