But Kightly managed only 10 appearances during the 2009-10 campaign, with his last game the 1-0 defeat at home to Birmingham on 29 November.
"It will be the same timescale as the last - six weeks to get him out running and then we will see from there," added McCarthy.
"The first knee he had done is brilliant, he is really buzzing about it, and the left knee that he has just had done wasn't half as bad as the other one."
Wolves have not put a timescale on Kightly's return to first-team action, but to feature in the Premier League this season he would need to be named in McCarthy's 25-man squad at the end of January.
And the Wolves boss gave hope to the player, saying: "We'll see. I don't know that we will have 25 players - it might be that I leave one berth open. We will see, but it would be lovely to have him back."
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