Sean O'Hanlon, Brian Howard and Stefani Miglioranzi are almost certainly out of Swindon's last two games of the season.
BBC Radio Swindon reports that defender O'Hanlon has a thigh strain, while midfielder Miglioranzi is on the sidelines with a knee problem.
Winger Howard, who will be out of contract in the summer, is struggling with a broken bone in his foot.
Star striker Sam Parkin is recovering from his hip injury, but may not be fit for Saturday's game at Huddersfield.
Meanwhile, Rory Fallon has decided to accept the offer of a place in the New Zealand squad for their game against Australia in London this June.
Initially the striker wanted to take the time off to rest, but has now decided a chance to win a first full cap is too good to turn down.